Why Relapse Patients Should Take LDN for Depression

When you are in the valley of depression, you would give anything to have someone pull you out.

You may have tried various things; listened to the advice of friends, gone to see a doctor, and taken the requisite medication.

You may even have been on the steady rise out.

But what if there was something that would let you soar out of the valley?

Taking LDN for depression might be just that boost. Let’s take a look at what there is out there on low dose naltrexone and see if it’s worth considering.

LDN For Depression: What Is It?

Naltrexone is an opiate antagonist.

It’s a chemical that works on the brain to prevent opiate effects. But it also decreases the desire to take opiates.

Many times it’s been used to treat alcohol and major drug abuse.

But LDN is a lower dose of the same drug. And it has some applications outside of drug addiction recovery including depression treatment.

How Does LDN Treat Depression?

Depression is both psychological and physical. One affects the other. And your nervous system is constantly under fire when you’re in a trough of depression.

Naltrexone works on two different receptors in your central nervous system. The opioid receptor and the TLR4 receptor.

One, as its name suggests, receives and uses opioids in the brain. The other works on your innate immune system and your inflammatory system.

This second part is the most important aspect of LDN for depression.

Your inflammatory system is the reason you feel pain when you’re depressed. And calming down your inflammatory system will help you physically feel better.

This combined with the calming of the opioid receptor helps you move to a higher functioning state.

You essentially begin to tolerate yourself.

If your immune system and your inflammatory system are not active, your body is no longer attacking itself. Your body literally tolerates itself when LDN is active in your body.

What Is The Dosage Of LDN?

Oddly, the lower the better for LDN dosage. LDN is typically 1/10th the dosage of Naltrexone for drug addiction.

Early studies have shown that 1-3mg at bedtime is sufficient for depression treatment.

Talk to your doctor about correct dosage. This is a prescription drug, but it has very few side effects.

You will have to go to a compounding pharmacy to get LDN as your regular pharmacy will only carry regular Naltrexone. And you won’t be able to split up a 50 mg pill into 50 parts. That’s just not possible.

Most insurance plans will cover LDN especially for depression.

Find out from your specific insurance provider if they will cover compounded ingredients, as these may not fit into their typical categories of generic or name brand medications.


If you are experiencing post relapse depression or pain from depression, talk to a professional to take the next steps toward Naltrexone treatment.

There is hope out there, and the first step to recovery is seeking help.

Have you had experience with LDN? Let us know in the comments below.

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